Recent developments
Brain & Cognitive Aging: What the Primary Evidence SupportsExercise is the best-evidenced lever for the aging brain. Across 39 RCTs, exercise improved cognition in adults 50+ with an overall effect of g = 0.29…SleepSleep is one of the few health behaviors where the underlying science is compelling and the popular messaging has outrun it. Both things are true at…Omega-3 and brain performance — memory, executive function, null in global cognitionOmega-3 fatty acids are frequently marketed for brain health, but the clinical evidence is more specific, and more modest, than the packaging implies.…NAD+ boosting & Alzheimer's — preclinical vs nullAlzheimer's research has a recurring problem: treatments that work brilliantly in mice often fail in people. NAD+ boosting is a sharp example of that…MIND diet — observational benefit vs RCT nullThe MIND diet, a hybrid of Mediterranean and DASH eating patterns built around leafy greens, berries, nuts, fish, and whole grains, has attracted…Glymphatic systemYour brain runs a cleaning cycle while you sleep. The system responsible is called the glymphatic pathway, and understanding how it works helps explain…Exercise and cognitive agingExercise is the most thoroughly evidenced modifiable factor for preserving cognitive function as you age. Two decades of randomized controlled trials…Creatine memory — meta-analysis double-countingThe most widely shared statistic about creatine and the brain, that it improves memory with an effect size of SMD 0.29, comes from a 2023 meta-analysis…Blood-brain barrierThe brain is picky about what it lets in. A structure called the blood-brain barrier (BBB) controls which molecules cross from the bloodstream into…APOE4 and omega-3 brain transport — paradoxical young uptake, old-age transporter failureCarrying one or two copies of the APOE4 allele is the most significant genetic risk factor for late-onset Alzheimer's disease, and its relationship…Alzheimer's diseaseAlzheimer's disease involves a measurable collapse in brain energy metabolism. AD brains show a reduced NAD+/NADH ratio and impaired cerebral energy…