Recent developments
MetforminMetformin is a cheap, decades-old diabetes drug that became the internet's favorite anti-aging pill. For people with type-2 diabetes, the enthusiasm is…Supplements & Compounds: What the Primary Evidence SupportsThis is an evidence hub for the compounds themselves. For each compound, the question is narrow: what does the primary literature (T1) support, what is…MagnesiumMagnesium sits at the center of more than 300 enzymatic reactions in the body, yet roughly half the population falls below the recommended daily…LycopeneLycopene is the carotenoid that gives tomatoes their red color. You absorb more of it from cooked and processed tomatoes (think paste and sauce) than…GLP-1 receptor agonistsGLP-1 receptor agonists, semaglutide (sold as Ozempic and Wegovy) and the dual GLP-1/GIP agonist tirzepatide (Mounjaro, Zepbound), are incretin-mimetic…CreatineCreatine is the most thoroughly studied supplement in sports science, and the evidence covers considerably more ground than gym performance. Here is…CanagliflozinCanagliflozin is a prescription drug best known as a diabetes medication, but it has drawn attention in longevity circles for a separate reason: it…BerberineBerberine is an isoquinoline alkaloid found in plants like barberry and goldenseal. It has earned a reputation as a "natural statin" because of its…Akkermansia muciniphilaAkkermansia muciniphila is a strict-anaerobic bacterium that lives in the mucin layer lining your intestinal wall. It has become one of the…AcarboseAcarbose is a prescription drug approved by the FDA for type 2 diabetes. It works by inhibiting alpha-glucosidase enzymes in the gut lining, slowing…17α-estradiol17α-estradiol is a naturally occurring epimer of standard estradiol, the "alpha" version of a molecule most people associate with feminizing effects.…