LampHill Letter: January 2026

This month covers two of the most contested topics in evidence-based nutrition, a metabolite most cardiologists have never heard of, and a genetic variant that reshapes Alzheimer's risk before symptoms appear. There is also a longevity compound that extends lifespan in male mice without feminizing effects, and a framework for training toward specific physical goals at age 88. The cell biology and fiber articles are quieter but grounded in unusually solid evidence.

This month's reading

Longevity. The cell's internal recycling system is tightly regulated, but what controls it and what happens when it fails? Autophagy

Cardiovascular. Metabolic poison or misunderstood staple: what does the evidence say about seed oils? Are seed oils uniquely harmful, the omega-6 debate

Brain. Alzheimer's may involve a measurable collapse in brain energy metabolism long before memory loss becomes obvious. Alzheimer's disease

Muscle. The question is not whether you will be healthy at 88, but whether you can still carry groceries upstairs. Centenarian decathlon

Nutrition. The evidence for eating more fiber is described here as about as solid as nutritional science gets. Dietary fiber

Supplements. A naturally occurring estradiol variant extends lifespan in male mice without the feminizing effects people assume. 17α-estradiol

Biomarkers. Researchers hunting cardiovascular risk beyond LDL found a niacin metabolite most clinicians have never measured. 4PY (niacin terminal metabolite)

Genetics. The variant you inherited shapes your Alzheimer's risk and your cholesterol handling in ways that are not yet fully separable. APOE4

Every claim in these guides links to its source. The full standard is on our about page.