LampHill Letter: March 2026

This month runs from the molecular to the measurable: what the blood-brain barrier controls, why EPA and DHA are not the same drug, and how to put a number on the muscle mass that predicts whether aging goes well or badly. Cold exposure also gets a fair hearing, which means some popular claims do not survive it.

This month's reading

Longevity. Cold exposure sits at a real physiological intersection, but the claims made about it have outrun what the physiology supports. Cold exposure

Cardiovascular. Treating EPA and DHA as interchangeable has already cost the clinical trial record, and probably some patients. EPA vs DHA

Brain. The brain controls exactly what crosses from your bloodstream into it, and the mechanism is more specific than most accounts suggest. Blood-brain barrier

Muscle. Omega-3s will not build muscle alone, but two specific contexts exist where EPA and DHA appear to do something measurable. Omega-3 and muscle health, disuse atrophy, anabolic sensitization, sarcopenia

Supplements. Akkermansia muciniphila lives in your gut's mucin layer and has become one of the more talked-about bacteria in longevity research. Akkermansia muciniphila

Biomarkers. ALMI puts a single normalized number on the arm and leg muscle that matters most for how aging unfolds. ALMI (appendicular lean mass index)

Every claim in these guides links to its source. The full standard is on our about page.