LampHill Letter: August 2026

This month leans hard on cardiovascular and metabolic territory: insulin's contested role in arterial disease, what CIMT measures, and muscle as something other than an aesthetic concern. Two articles will likely disappoint people hoping for shortcuts on fasting and NAD+, for good reason.

This month's reading

Longevity. Controlled studies on time-restricted eating tell a more complicated story than the wellness consensus suggests. Fasting & time-restricted eating

Cardiovascular. Whether hyperinsulinemia itself drives arterial disease, or travels with it, is a harder question than it looks. Insulin and atherosclerosis

Brain. NAD+ boosting is a precise case study in why mouse results and human results keep pointing in opposite directions. NAD+ boosting & Alzheimer's, preclinical vs null

Muscle. Muscle disposes of glucose, stores amino acids, and signals across the body in ways that have little to do with strength. Skeletal muscle (organ of longevity)

Nutrition. Gut bacteria fermenting fiber produce SCFAs, and butyrate appears to be doing most of the interesting work. Short-chain fatty acids (SCFAs)

Supplements. You absorb more lycopene from tomato paste than fresh tomatoes, which changes what the supplement question is about. Lycopene

Biomarkers. A carotid ultrasound measuring artery wall thickness requires no radiation and no contrast agent, so why is it still underused? CIMT

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